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            [post_date] => 2015-01-06 10:52:36
            [post_date_gmt] => 2015-01-06 10:52:36
            [post_content] => The Nauta® Cyclomix is a multi-purpose, high-shear impact mixer that is suitable for a variety of applications. It combines different processes in one single machine and is the ideal choice for intensive thermal processing of high energy input; high degree of dispersion and homogeneity and ultra-short cycle times.
  • Intensive mixing of cohesive powders, slurries and liquids
  • Agglomeration by temperature or moisture addition
  • Coating of powders with powders or liquids
  • Dispersion of pigments
  • Metallic bonding processing of powder paints
  • (Vacuum) drying at low temperature with liquid recovery
  • Low-speed mixing of cohesive powders, slurries and liquids
  • Densification of powders
  • Spheronization of particles
  • Grinding & de-agglomeration
  • Heating and cooling
  • Chemical reactions
[post_title] => Nauta® Cyclomix [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => vrieco-nauta-cyclomix [to_ping] => [pinged] => [post_modified] => 2020-12-15 12:43:48 [post_modified_gmt] => 2020-12-15 17:43:48 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 0 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [1] => WP_Post Object ( [ID] => 1088 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] => [post_title] => Nauta® Modulomix [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => vrieco-nauta-modulomix [to_ping] => [pinged] => [post_modified] => 2021-05-22 02:38:29 [post_modified_gmt] => 2021-05-22 06:38:29 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 0 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [2] => WP_Post Object ( [ID] => 1087 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] => The Vitomix is equipped with two symmetrical ribbon screws mounted on an orbital arm that transports the product from the bottom of the vessel to the surface. The material flows downwards through the center of the vessel by gravity whilst the high rotational speed of the agitator ensures mid-shear mixing in very short batch times. A distinctive factor about the Vitomix is the double ribbon screw which enables a transport capacity of up to eight times that of standard conical screw mixers. The result is a substantial improvement in mixing efficiency and a much more efficient and faster mixing process even at lower speeds. The design of the two conical screws creates a fluidized bed in the upper part of the mixer cone that is perfect for adding liquids. A liquid spraying system can be fitted through the hollow axle, providing flexibility in the location and the number of nozzles and lances you choose; without influencing mixing properties or spraying on metal parts. The Hosokawa Vitomix can be tailored for use in a wide variety of applications, these include:
  • Fast mixing of powders, pastes and slurries
  • Addition of liquids and fats without the use of lumpbreakers
  • Gentle mixing combined with mid shear mixing in one machine
  • Coating powders with powders
  • Granulating
  • Flavoring
  • Coloring
  • Heating / cooling
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In an Active Freeze Dryer, the product is first frozen dynamically by moving it in a specially designed chamber. Whether the material to be dried starts off as a liquid, granular solid or paste, the forced motion inside the drying chamber ensures that it freezes in the form of free-flowing solid granules.

Once the product is fully frozen, a deep vacuum is applied and the sublimation starts. Heat applied to the vessel jacket is effectively distributed throughout the product due to the dynamic environment. The initially coarse, frozen granules gradually shrink as the ice structure connecting the frozen material sublimes, yielding a loose powder consisting of fine, dry particles.

As the solvent disappears, the product temperature starts to rise until it equals the jacket temperature. This marks the end of the drying process. Once the vacuum has been released, the chamber is opened and the powdered product can be discharged.

Typical applications include pharmaceuticals like antibiotics, proteins, collagens, APIs and electrolytes. This new technology has also proven its suitability to the freeze drying of special materials like nano-materials, polymers, ceramics, pigments, fillers, lime stone, catalysts, glass powder and salts.

[post_title] => Nauta® Active Freeze Dryer [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => vrieco-nauta-active-freeze-dryer [to_ping] => [pinged] => [post_modified] => 2021-05-22 02:46:09 [post_modified_gmt] => 2021-05-22 06:46:09 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 0 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [5] => WP_Post Object ( [ID] => 1084 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] => [post_title] => Nauta® Vacuum Dryers [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => vrieco-nauta-vacuum-dryers [to_ping] => [pinged] => [post_modified] => 2020-10-28 12:41:36 [post_modified_gmt] => 2020-10-28 16:41:36 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 0 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) )

Dry Granulation of Pharmaceuticals

Dry Granulation of Pharmaceuticals

Application: In case of low bulk densities, bad flowing properties and the risk of segregation of the mixture tableting machines have problems to press high quality tablets which are required in the Pharmaceutical Industry. To press these mixtures a granulation technology is required to change the material behavior to god flowing, higher bulk density and reduce the tendency of segregation.

Tableting machines can typically operate with granules at higher speeds than with powders. The cheapest way of granulation in case of high amount of active ingredient is dry granulation where on liquid binder are necessary.

Process: The pharmaceutical blend is fed into the feed hopper of the compactor where an auger is feeding the material into the nip of the rolls. Between the rolls the powder is pressed to so called flakes. In a subsequent Flake Crusher the flakes will be broken to granules. The typical granule size varies to 10 to 18 mesh. Typical these processes requires machines which are easy to clean and guarantee a high quality of the produced granules. The quality of the granules needs to be validated.

Example: Feeding material: Pharmaceutical blend, bulk density: 200 ÔÇô 350 g/l, due to very fine active ingredients the flowing will be very bad.

  • Pharmapaktor APC L 200/50 for throughputs 80 to 120 kg/h
  • Pharmapaktor APC K Series
  • Size 200 for throughputs up to 250 kg/h
  • Size 300 for throughputs up to 800 kg/h
  • Pharmapaktor APC C 250
  • For throughputs from 100 to 300 kg/h for various products which require very different settings

Granulation is carried out for various reasons, one of which is to prevent the segregation of the constituents of powder mix. Segregation is due to differences in the size or density of the component of the mix. Normally, the smaller and/or denser particles tend to concentrate at the base of the container with the larger and/or less dense ones on the top. An ideal granulation will contain all the constituents of the mix in the correct proportion in each granule and segregation of granules will not occur.

Many powders, because of their small size, irregular shape or surface characteristics, are cohesive and do not flow well. Granules produced from such a cohesive system will be larger and more isodiametric, both factors contributing to improved flow properties.

Some powders are difficult to compact even if a readily compactable adhesive is included in the mix, but granules of the same powders are often more easily compacted. This is associated with the distribution of the adhesive within the granule and is a function of the method employed to produce the granule.

The dry granulation process is used to form granules without using a liquid solution because the product granulated may be sensitive to moisture and heat. Forming granules without moisture requires compacting and densifying the powders. In this process the primary powder particles are aggregated under high pressure. Sweying granulator or a high-shear mixer-granulator can be used for the dry granulation.

Dry granulation can be conducted under two processes; either a large tablet (slug) is produced in a heavy duty tabletting press or the powder is squeezed between two counter-rotating rollers to produce a continuous sheet or ribbon of materials (roller compactor, commonly referred to as a chilsonator which received its name from its inventor, Francis Xavier Chilson).

When a tablet press is used for dry granulation, the powders may not possess enough natural flow to feed the product uniformly into the die cavity, resulting in varying degrees of densification. The roller compactor (granulator-compactor) uses an auger-feed system that will consistently deliver powder uniformly between two pressure rollers. The powders are compacted into a ribbon or small pellets between these rollers and milled through a low-shear mill. When the product is compacted properly, then it can be passed through a mill and final blend before tablet compression.]