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            [post_title] => Micron Xerbis Agitated Media Flash Dryer
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            [post_content] => The Mikro Pulverizer® consists of a high speed rotor assembly fitted with hammers. The grinding chamber is fitted with a cover containing a multiple deflector liner and a retaining screen at the point of mill discharge.

A screw mechanism is often used to introduce feed material into the grinding chamber. The grinding process is affected by three basic variables: the type of hammers, the rotor speed, and the size and shape of the screen opening.

There are two types of hammers: the “stirrup,” recommended where a fine particle size is desired; and the “bar,” which generates a coarser grind with a minimum of fines. Both types are tipped at the wearing edge with various abrasion resistant alloys. Rotor speed affects the fineness of the grind as follows: low speeds result in a coarse grind and high speeds produce a fine grind. Size and shape of the retaining screen openings also affect the product. In general, a finer screen opening will result in a finer grind. The retaining screen does not function as a sifting screen, except in coarse granulations.
Controlled Particle Size
Optimum particle size reduction can greatly affect chemical reaction speeds, solubility, weight, color, volume, appearance and strength of ground products. Mikro-Pulverizers® provide accuracy in particle size control because the grinding action is entirely mechanical. Once a mill is set to deliver a certain product, it will continue to produce exactly the same result without adjustment.
Grind, Blend and Disperse
Mikro Pulverizers® grind, blend and disperse in a single operation. Intensive action thoroughly mixes dissimilar ingredients into a finished product. Heat sensitive materials are handled by adjustment of mill speed, hammers, screen and discharge air relief, as well as with pneumatic conveying. Conditioned air may be bled into a grinding chamber, or the feed may be pre-conditioned or chilled. The Mikro Pulverizers® comes in many model sizes from small pilot scale to massive production models. [post_title] => Mikro Pulverizer® Hammer & Screen Mill [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => mikro-pulverizer-hammer-and-screen-mill [to_ping] => [pinged] => [post_modified] => 2022-01-24 09:13:15 [post_modified_gmt] => 2022-01-24 14:13:15 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 5 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [2] => WP_Post Object ( [ID] => 1039 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] => Prior to the development of the Mikro LGM® Long Gap Mill, materials had to be dried and de-agglomerated in two separate operations. For example, a rotary drum dryer was used to dry materials that had been wet milled. A separate grinding/de-agglomeration process followed the drying operation. The Mikro LGM® Long Gap Mill is Hosokawa's solution for streamlining these two operations into one continuous process. This type of dryer is commonly referred to as a "gap" type mill. It is called a "long" gap mill because of the long annular gap path the process material takes from the inlet to the discharge. By combining several operations such as flash drying, de-agglomeration and surface coating into one operation, a Mikro LGM® Long Gap Mill eliminates the need for multiple material handling systems which subsequently increases process efficiencies. The dried powders often do not require any further size reduction. Both slurries and wet cake can be handled. The Mikro LGM® Long Gap Mill modular design expands its range of applications beyond drying and deagglomeration. For dry grinding, modular options include: direct and independent drive classifiers; pre-grind rotor stage; an integrated jet mill and variable stage rotor design. The smaller size Mikro LGM® Long Gap Mills are engineered with a split body housing for easy maintenance and cleaning. The LGM processes high moisture materials in wet cake form as well as dry solid feed stocks up to one inch. Finished product particle sizes of D97 < 10 microns can be achieved. The Mikro LGM® Long Gap Mill has demonstrated superior performance over all other mechanical mills in reducing grit from pre-sized and agglomerated powders. Typical results are less than 1 part per million (ppm) residue on a 44 micron sieve starting from a feed stock with a residue of 120 ppm. This performance is achieved with a powerful grinding mechanism coupled with a precision internal air classifier. The air classifier is designed for a theoretical cut point of 2-5 microns, depending on the particle density. Rejected particles are forced away from the classifier wheel and redirected outside of the mill back to the material inlet using a patented re-circulation system. [post_title] => Mikro LGM ® Long Gap Mill [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => mikro-lgm-long-gap-mill [to_ping] => [pinged] => [post_modified] => 2021-05-03 11:55:51 [post_modified_gmt] => 2021-05-03 15:55:51 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 7 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [3] => WP_Post Object ( [ID] => 1061 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] =>

Mikro ACM® Air Classifying Mills were invented by HMPS in the late 1960’s and are one of the most versatile types of size reduction equipment available in the market. These units while being capable of producing fine, medium and coarse grinds for a wide variety of materials for Food, Pharmaceutical, Chemical and Mineral industries, require very little maintenance over their life span. The basic design of these mills is the impact size reduction that is coupled with an internal dynamic classifier which controls the outlet (product) particle size via recirculating the coarse particles back into the grinding zone.

There are seven main factors which determine particle size distribution for the Mikro ACM® Air Classifying Mill. When varied, the rotor type and speed combined with the liner and hammer count affects the production of fines. The separator type and speed affects the top size of the product. And lastly, the airflow governs the throughput as well as top size and fines generation. With the endless available options a machine can be configured to process just about any material that is below MOH’s hardness of 5.

[post_title] => Mikro ACM® Air Classifying Mill [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => mikro-acm-air-classifying-mill [to_ping] => [pinged] => [post_modified] => 2021-07-29 11:28:37 [post_modified_gmt] => 2021-07-29 15:28:37 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 4 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [4] => WP_Post Object ( [ID] => 1132 [post_author] => 2 [post_date] => 2016-08-31 07:10:30 [post_date_gmt] => 2016-08-31 07:10:30 [post_content] => [post_title] => Nauta® Conical Screw Mixers 80, 200 & 1,200 liters [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => vrieco-nauta-conical-screw-mixers-80-200-and-1-200-liters [to_ping] => [pinged] => [post_modified] => 2021-05-22 02:35:37 [post_modified_gmt] => 2021-05-22 06:35:37 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 0 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [5] => WP_Post Object ( [ID] => 1086 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] => [post_title] => Micron Labomixer LV [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => micron-labomixer-lv [to_ping] => [pinged] => [post_modified] => 2021-04-22 08:20:49 [post_modified_gmt] => 2021-04-22 12:20:49 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 15 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [6] => WP_Post Object ( [ID] => 1085 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] =>

In an Active Freeze Dryer, the product is first frozen dynamically by moving it in a specially designed chamber. Whether the material to be dried starts off as a liquid, granular solid or paste, the forced motion inside the drying chamber ensures that it freezes in the form of free-flowing solid granules.

Once the product is fully frozen, a deep vacuum is applied and the sublimation starts. Heat applied to the vessel jacket is effectively distributed throughout the product due to the dynamic environment. The initially coarse, frozen granules gradually shrink as the ice structure connecting the frozen material sublimes, yielding a loose powder consisting of fine, dry particles.

As the solvent disappears, the product temperature starts to rise until it equals the jacket temperature. This marks the end of the drying process. Once the vacuum has been released, the chamber is opened and the powdered product can be discharged.

Typical applications include pharmaceuticals like antibiotics, proteins, collagens, APIs and electrolytes. This new technology has also proven its suitability to the freeze drying of special materials like nano-materials, polymers, ceramics, pigments, fillers, lime stone, catalysts, glass powder and salts.

[post_title] => Nauta® Active Freeze Dryer [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => vrieco-nauta-active-freeze-dryer [to_ping] => [pinged] => [post_modified] => 2021-05-22 02:46:09 [post_modified_gmt] => 2021-05-22 06:46:09 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 0 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [7] => WP_Post Object ( [ID] => 1084 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] => [post_title] => Nauta® Vacuum Dryers [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => vrieco-nauta-vacuum-dryers [to_ping] => [pinged] => [post_modified] => 2020-10-28 12:41:36 [post_modified_gmt] => 2020-10-28 16:41:36 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 0 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [8] => WP_Post Object ( [ID] => 1038 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] => [post_title] => Alpine Picoline [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => alpine-picoline [to_ping] => [pinged] => [post_modified] => 2021-05-12 10:27:13 [post_modified_gmt] => 2021-05-12 14:27:13 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 18 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [9] => WP_Post Object ( [ID] => 1081 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] =>

Protected by additional patents, the TTSP tandem toner classifier is a refinement of the TSP toner classifier, primarily with the aim of improving the precision of cut even further by means of two consecutive classifying stages. At the same product loading of the classifying air, the tandem toner classifier achieves a much higher precision of cut than the TSP, or at a constant coarse product quality, achieves a higher loading factor. This makes it possible to almost treble the throughput in comparison with the TSP.

Because of the dust explosion hazard associated with processing toner, the classifiers are designed to be explosion-pressure-shock-proof to 10 bar over-pressure.

[post_title] => Alpine TTSP Toner Classifier [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => alpine-ttsp-toner-classifier [to_ping] => [pinged] => [post_modified] => 2021-05-22 02:46:22 [post_modified_gmt] => 2021-05-22 06:46:22 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 0 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [10] => WP_Post Object ( [ID] => 1080 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] => [post_title] => Alpine TTC Turbo Twin Air Classifier [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => alpine-ttc-turbo-twin-air-classifier [to_ping] => [pinged] => [post_modified] => 2021-05-22 02:46:28 [post_modified_gmt] => 2021-05-22 06:46:28 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 0 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [11] => WP_Post Object ( [ID] => 1046 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] => [post_title] => Polymer Systems Hot Melt Granulator [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => polymer-systems-hot-melt-granulator [to_ping] => [pinged] => [post_modified] => 2021-05-22 02:46:00 [post_modified_gmt] => 2021-05-22 06:46:00 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 0 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [12] => WP_Post Object ( [ID] => 1037 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] =>

Shurfeed™ cutting chamber design allows material to fall directly in front of the rotating knives and to be pulled quickly through the cutting action for fast, complete granulation without piece bounce and flyback. Three steep angle rotor knives and two bed knives mounted in Double Angle Cut™ configurations reduce energy consumption, noise, heat and fines, while increasing throughput.

Shurfeed® cutting chamber design allows material to fall directly in front of rotating knives to be pulled quickly through the cutting action for fast, complete granulation without piece bounce and flyback. Only Polymer Systems gives a clear, unobstructed feed opening equal to rotor diameter for maximum performance through every inch of the cutting circle. This unique design maximizes granulator capacity, eliminates bottlenecks at the entrance to the cutting chamber and dramatically increases effective screen area for fast throughput. Ask for a comparison!

[post_title] => Polymer Systems Shurfeed 2000 Granulator [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => polymer-systems-shurfeed-2000-granulator [to_ping] => [pinged] => [post_modified] => 2020-10-25 13:34:43 [post_modified_gmt] => 2020-10-25 17:34:43 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 0 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [13] => WP_Post Object ( [ID] => 1062 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] => [post_title] => Micron Pulvis Agitating Media Mill [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => micron-pulvis-air-classifying-mill [to_ping] => [pinged] => [post_modified] => 2021-05-22 02:38:56 [post_modified_gmt] => 2021-05-22 06:38:56 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 20 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [14] => WP_Post Object ( [ID] => 1076 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] => The Mikro® Classifier is characterized by its optimized cyclone-classifier principle. Because of the optimized flow pattern and the use of a high-efficiency classifying wheel, the Mikro® Classifier is especially suitable for ultrafine classifying operations in in-line mode.

The feed product is fed tangentially to the top of the classifier. The classifying wheel separates the feed product into a coarse fraction and a fines fraction. The classifying air and the fines pass through the classifier wheel, whereas the coarse material settles on the housing wall. A flow of secondary air introduced tangentially above the product discharge recirculates any unclassified material to the classifying wheel for renewed classification, whereby agglomerates are dispersed and the material is then distributed uniformly in the classifying zone. The optimized classifying wheel geometry results in a high product yield at an extremely high precision of cut. In addition, the low pressure drops result in low energy consumption and correspondingly lower operating costs.

The Mikro® Classifier was designed for all types of fine to medium-fine products. It is especially suitable for powder coating classification aimed at reducing the ultrafine portion under 5 – 10 µm.

[post_title] => Mikro® CC Air Classifier [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => mikro-classifier [to_ping] => [pinged] => [post_modified] => 2021-05-22 02:46:44 [post_modified_gmt] => 2021-05-22 06:46:44 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 0 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [15] => WP_Post Object ( [ID] => 1074 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] =>

As requirements in the pharmaceutical industry continue to ask for tighter particle distributions, additional steps such as on-line classification may be required. The Mikro® Acucut Air Classifier utilizes dual stage operating controls to ensure sharp cuts and narrow band particle size distributions typically below the 10 micron range. This permits control of maximum and minimum particle size diameters with unparalleled accuracy. With precise control of the air flow and rotor speeds this unit will produce the same sharp cuts each time, every time. The high energy dispersion also ensures that the maximum percentage of fines is reclaimed. Easily operated, cleaned and maintained, the Mikro® Acucut Air Classifierr keeps downtime to a minimum.

Options are available for effective control of product contamination, protection against corrosion, handling abrasive materials and classifying adhesive powders. The Mikro® Acucut Air Classifier is ideal for chromatography materials, alumina, silica, toner and metal powders. Extremely high dispersive energy applied to the process material ensures unparalleled yields even with sticky and difficult to disperse products.

The Mikro® Acucut Air Classifier is a forced vortex unit designed to disperse, then classify fine particles into coarse and fine fractions. High energy dispersing air enters the rotor radially around the entire outer edge. Feed material enters this dispersion air zone through an inlet in the rotor ring. Particles are acted upon by centrifugal and drag forces. Air carries the dispersed fines inward to the central fractions outlet, coarse move outward to the rotor periphery. Cut points are adjusted by airflow, rotor speed or both.

[post_title] => Mikro® Acucut Air Classifier [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => mikro-acucut-air-classifier [to_ping] => [pinged] => [post_modified] => 2020-10-28 19:04:45 [post_modified_gmt] => 2020-10-28 23:04:45 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 0 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [16] => WP_Post Object ( [ID] => 1070 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] => [post_title] => Alpine ATR Vertical Dry Media Mill [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => alpine-atr-vertical-dry-media-mill [to_ping] => [pinged] => [post_modified] => 2021-05-22 02:52:43 [post_modified_gmt] => 2021-05-22 06:52:43 [post_content_filtered] => [post_parent] => 0 [guid] => [menu_order] => 18 [post_type] => hm-products [post_mime_type] => [comment_count] => 0 [filter] => raw ) [17] => WP_Post Object ( [ID] => 1103 [post_author] => 2 [post_date] => 2015-01-06 10:52:36 [post_date_gmt] => 2015-01-06 10:52:36 [post_content] =>


  • Applications:  While most customers use the air jet sieve to determine the particle size of dry powder ranging from as fine as 20 µm / #635 (mesh) up to 4,750 µm / #4 (mesh), some utilize the particle size analyzer to determine the average particle size below a specified cut point; such as D90 < 50 µm.  Others use the air jet sieve to confirm that a powder top size does not exceed product specifications. The Mikro Air Jet Sieve® MAJSx can even be used as a small lab-scale classifier to remove the fine particles out of a sample or as a dedusting system to remove undesirable dust from small batches.

    How it Works: The Mikro Air Jet Sieve® MAJSx utilizes test sieve screens and the pneumatic sieving principle to enhance the accuracy and reproducibility of particle size analysis. This method has become the preferred standard for such tasks as quality assurance of incoming raw materials, process control, and verification of final product specifications. While under negative pressure, a positive upward air flow is emitted from the rotating slit wand which continuously disperses particles across the surface of a test sieve screen. Those particles that are smaller then the opening of the test sieve screen pass through and are carried away from the sample, leaving the particles larger than the sieve opening on top of the test sieve screen. Particle size within the range of 20 to 4,750 µm can quickly be determined. The unique rotating slit wand feature also reduces, and in many cases, eliminates the need for tapping or brushing, thus enhancing the analysis reproducibility. The overall system is designed for cleaner operation and requires less counter space than other types of analytical equipment.

    Key Operating Parameters Enhance Repeatability & Reliability: The sieving time plays a major role in determining particle size with an air jet sieve. Excessive sieving time can lead to particle degradation due to attrition. In most dry powder applications, Hosokawa recommends a two-minute sieving time cycle which provides ample time for the particles of the entire sample to pass through the sieve screen or be retained.

    Sieving vacuum pressure between 8-16 inches of water column is recommended during a sieve analysis. If the pressure is too low, the air velocity passing through the rotating wand may not be sufficient to evenly disperse the entire sample. If the pressure is too high, the air velocity could generate enough force to further grind material as the sample repeatedly impacts the sieve screen and sieve cover.

    A sample volume between 10 and 100 grams is recommended in most air jet sieve particle analyzers, depending on the density of the material being tested. Samples larger than 100 grams have the potential to blind the test sieve screen and affect the analysis results.

    Test sieve screen quality and integrity is critical in any particle size analysis process. Hosokawa provides test sieve screens that are 99% accurate. Test sieve screens with damage such as holes, tears, scratches, waves, or other imperfections are not recommended. Sieve screens should be routinely re-certified to insure accurate analysis results.

    Performance at an Economical Cost: Certified pre-owned Hosokawa Air Jet Sieves analyzers start at $4,400. Prices can vary dependent on the number of sieve screens required, vacuum selection, balance type, optional components, taxes, and shipping.

    • Pre-Owned Air Jet Sieve Particle Size Analyzers – from $4,400

    Price Disclaimer: Prices listed are subject to change without warning and do not include taxes, shipping, or import fees or the cost of any accessories or ancillary equipment not included in the quotation.

    American Made: A long-time industry leader, Hosokawa developed air jet sieving technology in the early 1960's and has refined and elevated its technology to meet the latest market needs. The Mikro Air Jet Sieve® MAJSx is manufactured in the U.S. and comes with our pledge for performance and dependability. These innovative products have earned a reputation for accuracy and reliability as evidenced by the thousands of installations worldwide. 

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  • Dry Powder Inhalation (DPI)

    Dry Powder Inhalation (DPI) is the most common form of inhaled treatment for diseases such as asthma, COPD, bronchitis and emphysema. Patients use a device called a dry powder inhaler to deliver the appropriate dosage of an Active Pharmaceutical Ingredient (API) into the patient lungs.

    These inhalation devices contain a powder mixture that is under pressure.  There are three main components of the powder mixture, the API, a carrier which is typically lactose and additives such as Magnesium Stearate and Lecithin for material flow control, etc.  Generally API’s are cohesive and amorphous.

    The API particle size distribution is generally between 1 to 5 microns.  As such, the API is dependent on a carrier with a much larger particle size distribution to carry the API from the inhaler into the mouth of the patient.  The API is released from the carrier and released into the patient’s lungs while the carrier stays in the patient’s throat and goes into the stomach.  The carrier particle size distribution is generally between 40 to 200 microns.  The API is a very small percentage (<2%) of the entire mixture with the carrier about 90%.  The rest are additives.

    Jet Mills (Spiral Jet Mills (AS)  or Fluidized Opposed Bed Jet Mills (AFG)  are generally used to mill the API down to the appropriate particle size distribution. The Spiral Jet Mill is the most commonly used type of Jet Mill to micronize the API.  This mill is preferred, due to its simple design, with no moving parts in the mill, its accessibility for cleaning and inspection.  This mill can also be designed with CIP/SIP options.  (Note: Other methods can be used to achieve the appropriate particle size distribution for API such as crystallization and spray drying.)

    The Fluidized Bed Opposed Jet Mill can also be used for API micronization.  It is typically selected over the Spiral Jet Mill, if a tight and steep particle size distribution is required.  This is achieved using the AFG internal dynamic classifier.  Changes to the particle size distribution are also easier with the AFG Mill.  The AFG Mill can be designed with CIP/SIP options and explosion containment.  The AFG Mill is able to micronize heat sensitive or sticky materials.  Comparing to the AS Mill the AFG Mil can be fed with a larger feed size.  Both types of Jet Mills can be designed inside of an isolator for OEL Containment Levels <1 µg/m3, 8 hrs. TWA.

    A wide variety of milling technologies can be used to micronize the carriers/excipients/additives which are much coarser than the API’s.  The typical milling technologies used are: the Fluidized Bed Opposed Jet Mill (AFG), Air Classifier Mill (ACM)  and Universal Mills (UMP  and UPZ) which are mechanical impact mills.  The UMP and UPZ Mills are used mainly as Pin Mills or Hammer and Screen Mills.  The Universal Mills have other rotor assemblies for coarser grinds.

    After the various DPI components are micronized they are then mixed in a Cyclomix , which is a High Shear/High Speed mixer to coat the API onto the excipients and to achieve a homogeneous mixture. The Cyclomix is preferred, due to the high energy that is imparted to the cohesive powder mixture.

    Hosokawa’s milling and mixing technologies range from lab scale (approximately 1 gram for milling and 0.1 L for mixing) to production size equipment.  All equipment is scalable from lab scale to production scale.