Alpine AFG

Alpine AFS

Alpine AHM

Alpine AL

Alpine APP

Alpine AS

Alpine Circoplex ZPS

Alpine Contraplex CW

Alpine Multiplex Zig-Zag Classifier

Alpine MZR

Alpine PDD Twin Screw Volumetric

Alpine Rotoplex Granulators

Alpine SO Super Orion

Alpine Stratoplex ASP

Alpine TFG

Alpine Toner TSP High Efficiency Toner Classifier

Alpine Toner TTSP High Efficiency Tandem Toner Classifier

Alpine TTC

Alpine TTG

Alpine Turboplex ATP High Efficiency Classifier

Alpine UPZ

Alpine Ventoplex High Volume Classifier

Carbon Black Processing

Flue Gas Desulfurization

Hosokawa Bepex Pharmapaktor

Hosokawa Peneto Analyzer PNT-N

Hosokawa Powder Characteristics Tester PT-X

Majac Acucut High Energy Air Classifier

Micron Agglomaster AGM

Micron Air Jet Sieve

Micron Denspack

Micron Drymeister

Micron Faculty

Micron Finetron Feeder

Micron Mechanofusion

Micron Nobilta

Micron Penetration Analyzer

Micron Pulvis

Micron Separator

Micron Victory Mill

Mikro ACM Air Classifying Mill

Mikro Bantam Hammer & Screen Mill

Mikro Classifier CC

Mikro High Efficiency Cyclone

Mikro LPM

Mikro Pneumatic Vibratory Feeder PF

Mikro-Atomizer

Mikro-Crusher

Mikro-LGM

Mikro-Pulverizer

Stott Hygienic Bulk Packaging Systems

Stott Laminar Flow Booth

Universal Mikro Pulverizer

Vitalair Downflow Booths

Vrieco-Nauta Active Freeze Dryer

Vrieco-Nauta Centro Screw Mixer (CM-Series)

Vrieco-Nauta Conical Screw Mixers

Vrieco-Nauta Cyclomix

Vrieco-Nauta Horizontal Ribbon Mixer

Vrieco-Nauta Isem Ball Segment Valves

Vrieco-Nauta Mixing Sensors

Vrieco-Nauta Silo Mixer

Vrieco-Nauta Vacuum Dryers

Vrieco-Nauta Vitomix

Alpine UPZ

The Alpine UPZ Fine Impact Mills are truly flexible. Designed with ultimate versatility in mind, this one unit can accomplish a multitude of size reduction tasks. A wide variety of grinding inserts are available through the entire line of mills. The mill is also offered with a counter-rotating (Contraplex) set of pins for added shear for difficult to mill products. The Pharma version of this work horse has been designed specifically for cGMP compliance from the ground up. Size reduction of soft to medium soft material can be accomplished at rates from 3 to 700 Kg/hr depending on feed material and final size requirements.

Alpine UPZ fine impact mills can also be integrated into Stott isolators. This arrangement provides a completely integrated system capable of containment levels as low as 1 microgram/cubic meter.

The pharma-grade UPZ mills, with a wide range of configurations available can meet most size reduction tasks. These units feature:

Features of the Pharma-Grade Alpine UPZ Fine Impact Mill

  • Monoblock design, which eliminates dead areas
  • EZ clean design
  • Smaller units can be dismantled and autoclaved
  • Full CIP/SIP systems
  • Cryo and inerted systems
  • 10 Bar design standard
  • Fully adjustable speed
  • Lubricated for life bearings
  • Interchangeable grinding tools

Simple Operation:
Operation of the mill is simple. Material is introduced to the mill via feed device such as a rotary air lock or volumetric/gravimetric feeder through the mill's inlet. The inlet directs the material to the grinding chambers center. The grinding toll rotates at high speed, creating centrifugal force that will accelerate the pharm-powder outwards. The particles outward flow hurls them at high speed against the pins or other grinding media where the impact will cause the particles to fracture. See figure 1.

Discharge:
While getting material into the mill is important, recovery of the milled material is key. The pharma-UPZ offers various configurations to conform to your existing plant equipment or if this is a new installation, we can provide the most economical designs. We offer tangential, suction tank, gravity and others. Figure 2 shows a simple gravity discharge system.

Cryogenic:
Certain compounds such as steroids or soft/sticky/ fatty or heat sensitive materials pose their own particular problems when size reduction is required. Embrittlement of the material is such that at room temperature it will smear or is too soft for impact reduction to take place. Also some materials are heat sensitive and will lose the required characteristics needed for the formulation to take place. Therefore, we offer cryo and chilled air systems to accomplish this task. By injection of chilled air or a cryogenic liquid (Nitrogen) the material can be brought below its embrittlement point to allow for easy milling or keep the material from getting too warm, thus degrading the potency of the product.

We offer a full range of processing options. As a custom builder of pharmaceutical processing equipment, we can provide full turnkey systems. With full Validation services available, Hosokawa is a true single source supply for pharmaceutical size reduction equipment and service.

Aseptic and Isolation:
Many of today's compounds can be toxic to the operator given exposure in sufficient amounts. Exposure to the process may also degrade the material. It is not uncommon in the pharmaceutical industry to isolate the process from the operator or provide an inert atmosphere for manufacturing. The Alpine UPZ is adapted to be placed inside containment booths. Through our sister companies, Hosokawa Stott & Hosokawa Vitalair, we can offer full integration in this area. This allows for a custom built system from a single source. We carefully research your project requirements fully analyzing each of the process steps. We work with you to develop a plan of operation so that the operator is comfortable with all the necessary steps in working with the isolation system. We then construct a full scale model and physically test the operation, check dimensions, develop SOP's and consult with the end user. Once all parties are satisfied as to operation and integration, it is then we start the manufacturing process.